Microsoft founder Bill Gates expressed his motive that he wants most of his fortune will be spent in Africa over the next 20 years.
Bill Gates wished to spend on improving health and education services.
The 69-year-old said that by unleashing human potential through health and education, every country in Africa should be on a path to prosperity.
Speaking in Ethiopia's capital Addis Ababa, he also urged Africa's young innovators to think about how to build Artificial Intelligence (AI) to improve healthcare on the continent.
Gates announced last month that he would give away 99% of his vast fortune - which he expects to reach $200bn (£150bn) - by 2045, by when his foundation planned to end its operations.
"I recently made a commitment that my wealth will be given away over the next 20 years. The majority of that funding will be spent on helping you address challenges here in Africa," he said in an address at the African Union (AU) headquarters.
Mozambique's former First Lady Graça Machel welcomed his announcement, saying it came in a "moment of crisis".
"We are counting on Mr Gates' steadfast commitment to continue walking this path of transformation alongside us," she said.
The US government has cut aid to Africa, including programmes to treat patients with HIV/Aids, as part of US President Donald Trump's "America First" policy, raising concerns about the future of healthcare on the continent.
Gates said his foundation, which has a long history of operating in Africa, would focus on improving primary healthcare.
"What we've learned is that helping the mother be healthy and have great nutrition before she gets pregnant, while she is pregnant, delivers the strongest results," he said.
"Ensuring the child receives good nutrition in their first four years as well makes all the difference."
In a message to young innovators, the tech billionaire noted that mobile phones had revolutionised banking in Africa, and argued that AI should now be used for the continent's benefit.
"Africa largely skipped traditional banking and now you have a chance, as you build your next generation healthcare systems, to think about how AI is built into that," he said.
Gates pointed to Rwanda as an example, saying it was already improving services using AI-enabled ultrasound to identify high-risk pregnancies.
The Gates Foundation said it had three priorities: ending preventable deaths of mothers and babies, ensuring the next generation grows up without having to suffer from deadly infectious diseases, and lifting millions of people out of poverty.
Along with Paul Allen, Gates founded Microsoft in 1975, and the company soon became a dominant force in software and other tech industries.
Gates has gradually stepped back from the company in recent decades, resigning as its chief executive in 2000 and as chairman in 2014.
He said he had been inspired to give away money by investor Warren Buffett and other philanthropists.
Source: BBC
Bd-pratidin English/ Afia
